Next Health Knowledge Base

Weight Optimization

• Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomized trials
• Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regarding glycaemic control and body weight reduction

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Hormone Optimization

• Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men: Individual Participant Data Meta-analyses
• Bioidentical Hormone Therapy
• Hormone Therapy for The Aging
• Clinical Study: Cause-specific mortality in women receiving hormone replacement therapy
• Video: Myths Associated with Menopause and HRT - Dr. Matthew
• Video Difference Between Bioidentical and Non-Bioidentical
• Safety Study: Compounded BHRT - New Study

Women

• Testosterone therapy for reduced libido in women
• Beneficial effects of testosterone therapy in women measured by the validated Menopause Rating Scale (MRS)

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Men

• Testosterone Therapy in Men with Hypogonadism Prevents Progression From Pediabetes to Type 2 Diabetes: Eight -Year Data From a Resgistry Study
• Cardiovascular Issues in Hypogonadism and Testosterone Therapy
• Hypogonadism and Metabolic Syndrome: Implications For Testosterone Therapy
• Long-term Testosterone Therapy in Hypogonadal Men Ameliorates Elements of the Metabolic Syndrome: An Observational, Long-Term Registry Study
• Testosterone Therapy in Men with Prostate Cancer: Scientific and Ethical Considerations
• Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia hypogonadal men with type 2 diabetes
• Testosterone therapy decreases subcutaneous fat and adiponectin in aging men
• Enclomiphene Citrate for the Treatment of Secondary Male Hypogonadism

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Regenerative Therapy

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Stem Cells

• Purified umbilical cord derived mesenchymal stem cell treatment in case of systemic lupus erythematosus
• Intravenous Transplants of Human Adipose-Derived Stem Cell Protect the Brain from Traumatic Brain Injury-Induced Neurodegeneration and Motor and Cognitive Impairments: Cell Graft Biodistribution and Soluble Factors in Young and Aged Rats
• Stem Cell Therapy
• Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiologic properties
• A Long-Term Follow-up Study of Intravenous Autologous Mesenchymal Stem Cell Transpalntation in Patients with Ischemic Stroke
• Intra-Articular Mesenchymal Stem Cell Injection for Knee Osteoarthritis: Mechanisms and Clinical Evidence
• FDA Clinical Research Trials Underway
• Predicting the Safety and Efficacy of Cell and Tissue Products Used for Repair of Damaged Tissue and Structures through Cell Growth and Maturation Pathways, March 2018
• Stem cell therapy reverses age-related osteoporosis in mice
• What is the impact of human umbilical cord mesenchymal stem cell transplantation on clinical treatment?

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Stem Cell Injections

• Knee joint injections and aspirations
• Intra-Articular Mesenchymal Stem Cell Injection for Knee Osteoarthritis: Mechanisms and Clinical Evidence

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Exosomes

• Exosomes- beyond stem cells for restorative therapy in stroke and neurological injury
• Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle
• Cell-derived Extracellular Vesicles Open New Perspectives for Cancer Research
• MSCs- Derived Exosomes and Neuroinflammation, Neurogenesis and Therapy of Traumatic Brain Injury
• Novel Cancer Treatments Using Engineered Exosomes to Disrupt Cancer's Immune Escape
• Extracellular Vesicles: Exosomes and Microvesicles, Integrators of Homeostasis
• Administration of Human Endothelial Colony Forming Cell-Derived Exosomes and miR-486-5p Protects Against Ischemia/Reperfusion Acute Kidney Injury
• Exosomes of male reproduction
• Exosomes in liver pathology
• Exosomal Therapy – a new frontier in regenerative medicine, April 2021 
• Harnessing the Power of Exosomes for Regenerative Therapies, January 2023 
• Stem Cell-Derived Exosome vs Stem Cell Therapy

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Therapeutic Plasma Exchange

• Video: Dr. Dobri Kiprov Conference Talk - Therapeutic Plasma Exchange - 25 minutes 
• Journal Article: Lipoprotein apheresis to treat elevated lipoprotein (a)
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• Clinical Study: Old plasma dilution reduces human biological age: a clinical Study 
• Clinical Study: Randomized Controlled Trial of Plasma Exchange for Alzheimer's: AMBAR Study Findings
• Clinical Study: AMBAR Study Demonstrates the Feasibility of Two Plasma Exchange Modalities for Alzheimer's Treatment 
• Educational Article: Intermittent Heterochronic Plasma Exchange as a Modality for Delaying Cellular Senescence—A Hypothesis‍
• Science Article: Therapeutic plasma exchange (TPE) and blood products – Implications for longevity and disease
• Clinical Study Review:  Novel Approach to Attenuate Age-Elevated Blood Factors through Repositioning Plasmapheresis
• Case Study: Case Report: Therapeutic and immunomodulatory effects of plasmapheresis in long-haul COVID 
• Educational Article: Plasmapheresis use cases 
• ‍Study Finds Medical Procedure That Rejuvenates Old Human Blood
• YOUNG BLOOD & LONGEVITY: THERAPEUTIC PLASMA EXCHANGE (TPE) TREATMENTS by Peter Diamandis

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NAD+

• Comparison of Oral Nicotinamide Adenine Dinucleotide (NADH) versus Conventional Therapy for Chronic Fatigue Syndrome
• COVID-19: NAD+ deficiency may predispose the aged, obese, and type 2 diabetics to mortality through its effect on SIRT1 activity
• Nicotinamide adenine dinucleotide emerges as a therapeutic target in aging and ischemic conditions
• Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review
• Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease
• A Case of Parkinson's Disease Symptom Reduction with Intravenous NAD+
• NAD+ Repletion Rescues Female Fertility during Reproductive Aging

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Ozone Therapy

• Ozone Therapy: A clinical review
• Clinical utility of ozone therapy for musculoskeletal disorders
• Ozone therapy as a primary and sole treatment for acute bacterial infection: case report
• Ozone therapy in conjunction with oral antibiotics as a successful primary and sole treatment for chronic septic prosthetic joint: review and case report
• Ozone and oxidation therapies as a solution to the emerging crisis in infectious disease management: a review of current knowledge and experience
• Ozone therapy in medicine and dentistry
• Ozone therapy: a potential therapeutic adjunct for improving female reproductive health
• A Plausible "Penny" Cost Effective Treatment for Corona Virus - Ozone Therapy
• Standard Dosing of Heparin Prophylaxis of Venous Thromboembolism 
• Ozone high dose therapy (OHT) improves mitochondrial bioenergetics in peripheral blood mononuclear cells
• Improves Mitochondrial Health 
• Adjuvant for COVID-19 therapy 
• Nitric Oxide Benefit 
• Ozone Dialysis 
• Critical Role of the Nitric Oxide/Reactive Oxygen Species Balance in Endothelial Progenitor Dysfunction
• Role of Ozone in Integrative Medicine 
• Effects of Major Ozone Autohemotherapy on Physical Functionality and Quality of Life in Fibromyalgia Syndrome: A Prospective Cross-sectional Study

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IV Therapy

• Folate, vitamin B6, and vitamin B12 intakes are negatively associated with the prevalence of hypertension: A national population-based study
• Evaluation of the biochemical effects of administration of intravenous nutrients using erythrocyte ATP/ADP ratios
• Intravenous vitamin c as a chemotherapy agent: a report on clinical cases
• Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients During Chemo-/Radiotherapy and Aftercare: Results of a Retrospective, Multicentre, Epidemiological Cohort Study in Germany
• Reduction of Fibromyalgia Symptoms Through Intravenous Nutrient Therapy: Results of a Pilot Clinical Trial
• Intravenous Nutrient Therapy: The "Myer's Cocktail"

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Peptides

Thymosin Alpha-1

• From lab to bedside: emerging clinical applications of thymosin ⍺1
• Thymosin alpha 1: Biological activities, applications and genetic engineering production
• Zadaxin (thymosin alpha1) for the treatment of viral hepatitis
• Thymosin Alpha 1 - A Peptide Immune Modulator with a Broad Range of Clinical Applications
• Immune Modulation with Thymosin Alpha 1
• Thymosin alpha 1 and HIV-1: recent advances and future perspectives

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Thymosin Beta-4

• Thymosin Beta -4
• Thymosin beta 4 synergizes with human granulocyte-macrophage colony- stimulating factor in maintaining bone marrow proliferation
• Thymosin Beta4: a multi-functional regenerative peptide. Basic properties and clinical applications  
• Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues
• Thymosin beta4: structure, function, and biological properties supporting current and future clinical applications
• Thymosin Beta-4 Induces Mouse Hair Growth
• Chapter Nine- Cardioprotection by Thymosin Beta 4

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BPC-157

• The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration
• Body protective compound -157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro
• Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing
• Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts
• Modulatory Effect of Gastric Pentadecapeptide BPC 157 on Angiogenesis in Muscle and Tendon Healing

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CJC-1295

• Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults
• Activation of the GH/IGF-1 axis by CJC-1295, a long acting GHRH analog, results in serum protein profile changes in normal adult subjects

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GKU Cu

• ‍GHK and DNA: Resetting the Human Genome to Health‍
• GHK-Cu Overview – Benefits, Side Effects & Dosages‍
• GHK-Cu | Reviews, Clinical Trials, and Safety

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Wellness Technology

Infrared LED

• 830 nm light-emitting diode low level light therapy (LED -LLLT) enhances wound healing: a preliminary study
• Clinical and experimental applications of NIR-LED photobiomodulation
• A study to determine the efficacy of combination LED light therapy (633 nm and 830 nm) in facial skin rejuvenation
• Mechanisms of Low Level Light Therapy

Infrared Sauna

• ‍Sauna: The facts, the myths, and the how-tos by Peter Attia

Hyperbaric Oxygen Therapy

• Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells : a prospective trial

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Labs

Vitamin D 

• Consensus statement from 2nd International Conference on Controversies in Vitamin D
• Vitamin D: What’s the Evidence?

Lp(a)

• Elevated Lp(a) Treatment Options

TruAge Epigenetic Test

• Epigenetic scores for the circulating proteome as tools for disease prediction
• Integration of DNA methylation datasets for individual prediction
• Blood-based epigenome-wide analyses of cognitive abilities
• Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health
• Unveiling the Epigenetic Impact of Vegan vs. Omnivorous Diets on Aging: Insights from the Twins Nutrition Study (TwiNS)

Longevity

Anti-Senescence

• Peter Attia : Targeting Senescence